WELCOME TO OUR PARKINSON'S PLACE!

I HAVE PARKINSON'S DISEASES AND THOUGHT IT WOULD BE NICE TO HAVE A PLACE WHERE THE CONTENTS OF UPDATED NEWS IS FOUND IN ONE PLACE. THAT IS WHY I BEGAN THIS BLOG.

I COPY NEWS ARTICLES PERTAINING TO RESEARCH, NEWS AND INFORMATION FOR PARKINSON'S DISEASE, DEMENTIA, THE BRAIN, DEPRESSION AND PARKINSON'S WITH DYSTONIA. I ALSO POST ABOUT FUNDRAISING FOR PARKINSON'S DISEASE AND EVENTS. I TRY TO BE UP-TO-DATE AS POSSIBLE.

I AM NOT RESPONSIBLE FOR IT'S CONTENTS. I AM JUST A COPIER OF INFORMATION SEARCHED ON THE COMPUTER. PLEASE UNDERSTAND THE COPIES ARE JUST THAT, COPIES AND AT TIMES, I AM UNABLE TO ENLARGE THE WORDING OR KEEP IT UNIFORMED AS I WISH. IT IS IMPORTANT TO UNDERSTAND I AM A PERSON WITH PARKINSON'S DISEASE. I HAVE NO MEDICAL EDUCATION,

I JUST WANT TO SHARE WITH YOU WHAT I READ ON THE INTERNET. IT IS UP TO YOU TO DECIDE WHETHER TO READ IT AND TALK IT OVER WITH YOUR DOCTOR. I AM JUST THE COPIER OF DOCUMENTS FROM THE COMPUTER. I DO NOT HAVE PROOF OF FACT OR FICTION OF THE ARTICLE. I ALSO TRY TO PLACE A LINK AT THE BOTTOM OF EACH ARTICLE TO SHOW WHERE I RECEIVED THE INFORMATION SO THAT YOU MAY WANT TO VISIT THEIR SITE.

THIS IS FOR YOU TO READ AND TO ALWAYS KEEP AN OPEN MIND.

PLEASE DISCUSS THIS WITH YOUR DOCTOR, SHOULD YOU HAVE ANY QUESTIONS, OR CONCERNS. NEVER DO ANYTHING WITHOUT TALKING TO YOUR DOCTOR FIRST..

I DO NOT MAKE ANY MONEY FROM THIS WEBSITE. I VOLUNTEER MY TIME TO HELP ALL OF US TO BE INFORMED.

I WILL NOT ACCEPT ANY ADVERTISEMENT OR HEALING POWERS, HEALING FROM HERBS AND ETC. UNLESS IT HAS GONE THROUGH TRIALS AND APPROVED BY FDA. IT WILL GO INTO SPAM.

THIS IS A FREE SITE FOR ALL WITH NO ADVERTISEMENTS

THANK YOU FOR VISITING! TOGETHER WE CAN MAKE A DIFFERENCE!

TRANSLATE

Friday, July 7, 2017

Scientists uncover the structure of tau filaments from Alzheimer's disease

July 6, 2017

PET scan of a human brain with Alzheimer's disease. Credit: public domain


Researchers at the MRC Laboratory of Molecular Biology (LMB) have, for the first time, revealed the atomic structures of one of the two types of the abnormal filaments which lead to Alzheimer's disease. Understanding the structures of these filaments will be key in developing drugs to prevent their formation. The researchers, whose study is published today in Nature, believe the structures they have uncovered could also suggest how tau protein may form different filaments in other neurodegenerative diseases.

Alzheimer's, the most common neurodegenerative disease, is characterised by the existence of two types of abnormal 'amyloid' forms of protein which form lesions in the brain. Tau forms filaments inside nerve cells and amyloid-beta forms filaments outside cells. Tau lesions appear to have a stronger correlation to the loss of cognitive ability in patients with the disease. 
Almost thirty years ago, scientists at the LMB (including Michel Goedert, one of the senior authors on this paper) identified tau protein as an integral component of the lesions found in Alzheimer's and a range of other neurodegenerative diseases.  But, until now, scientists have been unable to identify the atomic structure of the filaments.
The researchers extracted tau filaments from the brain of a patient who had died with Alzheimer's disease. The filaments were then imaged using cryo-electron microscopy (cryo-EM). Senior author Sjors Scheres and colleagues developed new software in order to calculate the structure of the filaments in sufficient detail to deduce the arrangement of the atoms inside them. 
Sjors Scheres said: "It's very exciting that we were able to use this new technique to visualise filaments from a diseased brain as previous work depended on artificial samples assembled in the laboratory.  Amyloid structures can form in many different ways, so it has been unclear how close these lab versions resembled those in human disease.
"Knowing which parts of tau are important for filament formation is relevant for the development of drugs. For example, many pharmaceutical companies are currently using different parts of tau in tests to measure the effect of different drugs on filament formation; this new knowledge should significantly increase the accuracy of such tests."
Fellow senior author Michel Goedert said: "We have known for almost three decades that the abnormal assembly of tau protein into filaments is a defining characteristic of Alzheimer's disease. In 1998, the dysfunction of tau protein was shown to be sufficient for neurodegeneration and dementia. In 2009, the prion-like properties of assembled tau were identified. These properties allow the abnormal form to convert previously normal forms.
"Until now the high-resolution structures of tau or any other disease-causing filaments from human brain tissue have remained unknown. This new work will help to develop better compounds for diagnosing and treating Alzheimer's and other diseases which involve defective tau."
Dr Rob Buckle, chief science officer at the MRC, which funded the research, said: "This ground-breaking work is a major contribution to our understanding of Alzheimer's disease. Nearly thirty years ago scientists at the LMB were the first to discover that tau protein plays a key role in the disease. Knowing the basic structure of these filaments in diseased tissue is vital for the development of drugs to combat their formation.
"This research opens up new possibilities to study a range of other diseases where the accumulation of abnormal protein filaments plays a role, including Parkinson's disease, motor neuron disease and prion diseases."
More information: Anthony W. P. Fitzpatrick et al. Cryo-EM structures of tau filaments from Alzheimer's disease, Nature (2017). DOI: 10.1038/nature23002
Journal reference: Nature
Provided by: Medical Research Council
https://medicalxpress.com/news/2017-07-atomic-protein-tangles-alzheimer-disease.html

1 comment:

  1. My daughter (Annabel) suffered schizophrenia for 5 years. I had no idea what was happening and didn’t know where to turn for help. It was hard then because I really didn’t understand the symptoms earlier until she was diagnosed. There was a time she decided to get away from everyone, I was not excluded. I had to sit and cry almost every day because I felt helpless as a single mother (she is all I have got). The anguish I went through taking care of her alone is beyond explanation because there was no support whatsoever from the dad or family members. I fought for proper medical care and humane treatment; I did everything within my reach to get her cured but all to no avail. Countless different medications was prescribed (Zyprexa, fluphenazine, Risperdal, quetiapine, etc.) that she was taking but all we could get was myriad of side effects such as rigidity, drowsiness, dizziness, tremors and restlessness which tends to worsen the already damaged situation. Frustration was the order of the day. I wrote a couple of messages to Ontario Mental Health Foundation for help because watching my daughter go through such was devastating. It was at this foundation someone shared a testimony about DR Sunday herbal medicine, how effective it is and how she went through the most difficult times of her life trying to help her mom fight Schizophrenia. Being that I was already at the verge of giving up because I just couldn't imagine waking up every morning to fight the same demons that left me so tired the night before. I had to contact the doctor,on his email  (drsundayherbalcenter@gmail.com)  from our conversations; I was relieved and convinced that the result is going to be positive because I was made to contact people with worse cases. Today, the awful situation of my daughter has gone by. Her happy life is back. She is now a schizophrenia survivor and I am glad because my daily routine activities can now kick off without obstructions. Don't let Schizophrenia hinder you from living a desired life and also, never allow anyone to decide for you especially when they don't know what you have to go through to get to where you are. I was almost discouraged by the doctor but then, I remembered that: I have to shield my daughter’s destiny with courage, faith and perseverance because she is not in her right state of mind and that the bravery and freedom from fear is found in the ‘doing’. Her life is now a testimony. After my daughter got cured,from the herbal mix medicine Dr Sunday prepared and sent to me, she said, Mom “I just thought, ‘Well, I’m a weirdo, I’ll never be normal, then I said, my daughter, life itself is a misery and we get stronger in the places we have been broken. Thanks to you Dr. Sunday  for your excellent counseling, no more psychotic symptoms for the past 3 years and 4 months now. To know more about Dr.Sunday and the effectiveness of his Herbs and roots extracts and he said he got cures for diseases like Bipolar,DIABETES, HPV,SHINGLES,CANCER, ALS, HEPATITIS B, KIDNEY DISEASE, HERPES, Ovarian Cancer,Pancreatic cancers, Bladder cancer,Skin cancer, Prostate cancer, Glaucoma., Cataracts,Macular degeneration,Cardiovascular disease,Autism,Lung disease.Enlarged prostate,Osteoporosis.Alzheimer's disease,psoriasis ,Tach Diseases,Lupus,Dementia.kidney cancer, lung cancer,. You can reach him on his Email at ... drsundayherbalcenter@gmail.com.  I believe you will testify just like me.

    ReplyDelete