I HAVE PARKINSON'S DISEASES AND THOUGHT IT WOULD BE NICE TO HAVE A PLACE WHERE THE CONTENTS OF UPDATED NEWS IS FOUND IN ONE PLACE. THAT IS WHY I BEGAN THIS BLOG.

I COPY NEWS ARTICLES PERTAINING TO RESEARCH, NEWS AND INFORMATION FOR PARKINSON'S DISEASE, DEMENTIA, THE BRAIN, DEPRESSION AND PARKINSON'S WITH DYSTONIA. I ALSO POST ABOUT FUNDRAISING FOR PARKINSON'S DISEASE AND EVENTS. I TRY TO BE UP-TO-DATE AS POSSIBLE.

I AM NOT RESPONSIBLE FOR IT'S CONTENTS. I AM JUST A COPIER OF INFORMATION SEARCHED ON THE COMPUTER. PLEASE UNDERSTAND THE COPIES ARE JUST THAT, COPIES AND AT TIMES, I AM UNABLE TO ENLARGE THE WORDING OR KEEP IT UNIFORMED AS I WISH. IT IS IMPORTANT TO UNDERSTAND I AM A PERSON WITH PARKINSON'S DISEASE. I HAVE NO MEDICAL EDUCATION,

I JUST WANT TO SHARE WITH YOU WHAT I READ ON THE INTERNET. IT IS UP TO YOU TO DECIDE WHETHER TO READ IT AND TALK IT OVER WITH YOUR DOCTOR. I AM JUST THE COPIER OF DOCUMENTS FROM THE COMPUTER. I DO NOT HAVE PROOF OF FACT OR FICTION OF THE ARTICLE. I ALSO TRY TO PLACE A LINK AT THE BOTTOM OF EACH ARTICLE TO SHOW WHERE I RECEIVED THE INFORMATION SO THAT YOU MAY WANT TO VISIT THEIR SITE.

THIS IS FOR YOU TO READ AND TO ALWAYS KEEP AN OPEN MIND.

PLEASE DISCUSS THIS WITH YOUR DOCTOR, SHOULD YOU HAVE ANY QUESTIONS, OR CONCERNS. NEVER DO ANYTHING WITHOUT TALKING TO YOUR DOCTOR FIRST..

I DO NOT MAKE ANY MONEY FROM THIS WEBSITE. I VOLUNTEER MY TIME TO HELP ALL OF US TO BE INFORMED.

I WILL NOT ACCEPT ANY ADVERTISEMENT OR HEALING POWERS, HEALING FROM HERBS AND ETC. UNLESS IT HAS GONE THROUGH TRIALS AND APPROVED BY FDA. IT WILL GO INTO SPAM.

THIS IS A FREE SITE FOR ALL WITH NO ADVERTISEMENTS

THANK YOU FOR VISITING! TOGETHER WE CAN MAKE A DIFFERENCE!

Wednesday, June 6, 2018

Study reveals how pesticides cause Parkinson's Disease

June 6, 2018 By Jack Davis

A recent study has shown that pesticides prevent mitochondria from functioning correctly, causing cell death in human neurons with increased susceptibility to Parkinson’s Disease.

Image Credit: Kateryna Kon / Shutterstock

The study, which was recently published in the FASEB Journal, found that even low levels of pesticide can lead to the development of Parkinson’s disease in those at risk of developing the condition.

Pesticides such as paraquat, maneb and rotenone have previously been shown to have an effect on Parkinson’s disease, but the latest research reveals how they have an effect, and was also carried out under conditions that more closely mimic human physiology.

Scott Ryan, a professor in the Department of Molecular and Cellular Biology at the University of Guelph explains that this study is very applicable to human cases.

"We are one of the first to investigate what is happening inside human cells” he explains, whereas most studies concerning the link of pesticides and Parkinson’s in the past have been based on animal studies.

The research team used human stem cells with a mutation in the α-synuclein gene, which is associated with increased risk of Parkinson’s, and transformed them into dopamine-producing neurones(the cells affected in the brain of patients with Parkinson’s disease).

The researchers found that when dopamine-producing neurones are exposed to pesticides, they produce nitric oxide (NO), which prevents the movement of mitochondria to areas of the nerve cell where it is needed most.

NO is involved in the modification of structures called microtubules which normally transport the mitochondria around the cell. A lack of mitochondrial transportation means that not enough energy is produced to maintain the cell.

The exact cause of Parkinson’s is still unknown, but we do know that it can develop due to the death of dopamine-producing neurones in certain areas of the brain, and therefore a lack of dopamine in these areas.

The resultant lack of mitochondrial energy causes the neuron to die, leading to Parkinson’s Disease.

The pesticide dose at which these neurones were exposed to was actually lower than the previously thought lowest observed effect level.

The results show that with some current laws, people can still be very likely to develop Parkinson’s disease after exposure to these pesticides, if they have certain mutations that give them a higher risk.

The production of nitric oxide can be stopped or slowed by the use of NOS inhibitors. These are molecules that inhibit the enzymes which generate nitric oxide. This study used the NOS inhibitor Nω-nitro-L-arginine methyl ester to stop the effects of the pesticide.

Source:

https://news.uoguelph.ca/2018/05/u-g-study-uncovers-cause-pesticide-exposure-parkinsons-link/ https://www.fasebj.org/doi/10.1096/fj.201700759RR

https://www.news-medical.net/news/20180606/Study-reveals-how-pesticides-cause-Parkinsons-Disease.aspx