|AXON Neuroscience's symposium called "Frontiers in diagnostics and therapy of human tauopathies" was held on April 1, 2017 at the 13th International Conference on Alzheimer's & Parkinson's Diseases (AD/PD 2017) in Vienna, Austria.|
Potential to treat Frontotemporal Dementia with Tau Vaccine
Data from AXON's Phase I study in Alzheimer's Disease demonstrates that the antibodies elicited by vaccination with AADvac1 could recognize pathological tau protein in Alzheimer's Disease brains. This data suggests that the antibody response in patients can stop or slow down the progression of the disease.
During AD/PD 2017, AXON's Medical Director,, presented additional analysis of AXON's 18-month Follow-up Study of the Phase I, which directly confirms that the antibodies elicited by vaccination with AADvac1 could recognize pathological tau protein also in Corticobasal Degeneration (CBD) and Progressive Supranuclear Palsy (PSP). This data displays that the antibodies produced by the vaccine target a common denominator of AD and FTD, in both of which tau pathology is the driver of the disease.
Pilot Phase I Study in nfvPPA - a subgroup of FTD
In the second quarter of 2017, AXON, in cooperation with the German FTLD Consortium, is initiating a pilot Phase I study with its active tau vaccine in nfvPPA patients. Currently, there is no disease-modifying treatment available for this indication.
Non-fluent variant of Primary Progressive Aphasia (nfvPPA)
The non-fluent variant of Primary Progressive Aphasia is a neurodegenerative disorder from the group of Frontotemporal Dementias, where tau pathology is one of the main drivers of the disease. During the initial phase of the disease, nfvPPA presents with a prominent, isolated language deficit. There is a progressive impairment of language during conversation or through speech. Other cognitive functions and motor problems may be also affected as the disease progresses.
AXON Neuroscience is a clinical-stage biotech company and a global leader in development of tau-immunotherapies. Researchers at AXON Neuroscience have worked extensively on the tau hypothesis for more than 25 years. AXON's focus is to deliver a disease-modifying drug and a diagnostic tool for Alzheimer's Disease and other Frontotemporal Dementias and bring a complex solution for people suffering from the devastating disease.