Takeaway
• Statin users were more likely to develop Parkinson's disease,
especially in the first few years of use and when taking the drugs with
nonstatin lipid-lowering drugs.
Why this matters
• A large share of the population takes statins, and their
association with neurologic conditions is unclear in part because of
publication bias.
Key results
• Statin users had an elevated risk for Parkinson's disease
relative to nonusers.
• In stratified analysis, risk was elevated for users of
lipophilic statins (OR, 1.58; P<.0001), but not users of hydrophilic
statins.
• Greatest elevation of risk was seen for individuals taking both
statins and nonstatin lipid-lowering medications (OR, 1.95; P<.0001).
• Odds were highest in the first year of use (OR, 1.82), fell
between 1 and 2.5 y (OR, 1.75), and fell even more thereafter (OR, 1.37) (Ptrend<.0001).
Study design
• A retrospective case-control study using claims data of 2322
patients with incident Parkinson's disease and 2322 matched control individuals
without the disease.
• The main outcome was Parkinson's disease.
• Funding: Tobacco Commonwealth Universal Research Enhancement
Program (CURE) General Clinical Research Center.
Limitations
• Only commercially insured individuals were included.
• Patients with Parkinson's disease were identified with diagnosis
codes.
• Lipid levels were not available.
References:
Liu G, Sterling NW, Kong L, Lewis MM, Mailman RB, Chen H, Leslie
D, Huang X. Statins may facilitate Parkinson's disease: Insight gained from a
large, national claims database. Mov Disord. 2017 Apr 3 [Epub ahead of print].
doi: 10.1002/mds.27006. PMID: 28370314
https://www.univadis.com/viewarticle/parkinson-s-disease-risk-found-higher-for-statin-users-503325?s1=news
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