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I copy news articles pertaining to research, news and information for Parkinson's disease, Dementia, the Brain, Depression and Parkinson's with Dystonia. I also post about Fundraising for Parkinson's disease and events. I try to be up-to-date as possible. I have Parkinson's
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Friday, April 7, 2017

Parkinson's disease risk found higher for statin users

April 6, 2017



Takeaway 
   
  Statin users were more likely to develop Parkinson's disease, especially in the first few years of use and when taking the drugs with nonstatin lipid-lowering drugs.

Why this matters
  A large share of the population takes statins, and their association with neurologic conditions is unclear in part because of publication bias.

Key results 
  Statin users had an elevated risk for Parkinson's disease relative to nonusers.
  In stratified analysis, risk was elevated for users of lipophilic statins (OR, 1.58; P<.0001), but not users of hydrophilic statins.
  Greatest elevation of risk was seen for individuals taking both statins and nonstatin lipid-lowering medications (OR, 1.95; P<.0001).
  Odds were highest in the first year of use (OR, 1.82), fell between 1 and 2.5 y (OR, 1.75), and fell even more thereafter (OR, 1.37) (Ptrend<.0001).

Study design
  A retrospective case-control study using claims data of 2322 patients with incident Parkinson's disease and 2322 matched control individuals without the disease.
  The main outcome was Parkinson's disease.
  Funding: Tobacco Commonwealth Universal Research Enhancement Program (CURE) General Clinical Research Center.

Limitations
  Only commercially insured individuals were included.
  Patients with Parkinson's disease were identified with diagnosis codes.
  Lipid levels were not available.

References:
Liu G, Sterling NW, Kong L, Lewis MM, Mailman RB, Chen H, Leslie D, Huang X. Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database. Mov Disord. 2017 Apr 3 [Epub ahead of print]. doi: 10.1002/mds.27006. PMID: 28370314

https://www.univadis.com/viewarticle/parkinson-s-disease-risk-found-higher-for-statin-users-503325?s1=news

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