Investigators from Neurodon LLC Zero in on Parkinson's Disease (A new target for Parkinson's disease: Small molecule
SERCA activator CDN1163ameliorates dyskinesia in 6-OHDA-lesioned rats)
News Reporter-Staff News Editor at Pain & Central Nervous System Week -- New research on Parkinson's disease is the subject of a report. According to news reporting out of Schererville, Indiana, by NewsRx editors, the research stated, "Endoplasmic reticulum (ER) stress is intimately linked to Parkinson's disease (PD) pathophysiology. Disrupted intracellular calcium homeostasis is a major cause of the ER stress seen in dopaminergic neurons, leading to the cell death and subsequent loss of movement and coordination in patients."
Our news journalists obtained a quote from the research from
Neurodon LLC, "Dysfunctional calcium handling proteins play a major role in the promulgation of ER stress in PD. Specifically, compromised sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) has been identified as a major cause of ER stress and neuron loss in PD. We have identified a small molecule activator of SERCA that increases ER calcium content, rescues neurons from ER stress-induced cell death in vitro, and shows significant efficacy in the rat 6-hydroxydopamine (6-OHDA) model of PD."
According to the news editors, the research concluded: "Together, these results support targeting
SERCA activation as a viable strategy to develop disease-modifying therapeutics for PD."
For more information on this research see: A new target for Parkinson's disease: Small molecule
SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats. Bioorganic & Medicinal Chemistry, 2017;25(1):53-57. Bioorganic & Medicinal Chemistry can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. ( Elsevier - www.elsevier.com; Bioorganic & Medicinal Chemistry - www.journals.elsevier.com/bioorganic-and-medicinal-chemistry/)
Our news journalists report that additional information may be obtained by contacting
R. Dahl, Neurodon LLC, Schererville, IN 46375, United States(see also Parkinson's Disease).
Keywords for this news article include:
Schererville, Indiana, United States, North and Central America, Central Nervous System Diseases and Conditions, Neurodegenerative Diseases and Conditions, Musculoskeletal Diseases and Conditions, Basal Ganglia Diseases and Conditions, Brain Diseases and Conditions, Neurologic Manifestations, Parkinsonian Disorders, Parkinson's Disease, Movement Disorders, Dyskinesias, Neurodon LLC.
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